Take Action for a Known Mutation

TAKE ACTION. Your patient meets criteria for an increased risk of hereditary cancer based on an identified mutation (pathogenic variant).

Your response to the initial assessment indicates that your patient has an increased risk based on a specific gene identified via tumor profiling and/or a blood relative with a known pathogenic variant in a cancer susceptibility gene. Your patient should be referred for genetic counseling and possible genetic testing for the specific pathogenic variant. Below are some resources for you and your patient.

Different hereditary cancer conditions cause increased risks in specific cancers. The most common syndromes are:

Other less-common syndromes are Li-Fraumeni Syndrome, Cowden Syndrome, Von Hippel Lindau (VHL), and Multiple Endocrine Neoplasia (MEN). Download fact sheet for less-common hereditary cancer conditions.

If you have questions or concerns about your patient’s personal or family medical history of cancer, contact a cancer genetics provider.

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